Summary of studies adopted by SMHRN
Addictions Bipolar Depression Eating Disorders Genetic Personality Disoder Learning Disabilities
Psychological Distress Psychosis Schizophrenia Unexplained Symptoms Aspergers Syndrome Autism Other


fNEMO
Neuropsychological function as a result of chronic exposure to methadone and other opiates (NEMO): neural responses to rewards - a study using functional magnetic resonance imaging (fMRI)
Chief Investigator
Dr Alex Baldacchino
MUP
Effects of Scottish Government changes in alcohol policy on consumption and purchasing of alcohol beverages by patients with alcohol-related health harms.
Chief Investigator
Professor Jonathan Chick
CARD
Compliance And Relapse in Detoxification (CARD) Compliance And Relapse in Detoxification (CARD)
Chief Investigator
Dr Iain Smith



A clinical, neuropsychological and magnetic resonance imaging study comparing autism spectrum disorders and schizophrenia spectrum disorders
Chief Investigator
Dr Andrew Stanfield
Multimodal Brain Imaging in Autism Spectrum Disorder
Chief Investigator
Ms Maria Dauvermann



Efficacy of a group based social skills intervention in adults with Asperger syndrome
Chief Investigator
Dr Andrew Stanfield



CEQUEL
Comparative Evaluation of QUEtiapine-Lamotrigine combination versus quetiapine monotherapy (and folic acid versus placebo) in patients with bipolar depression.
Chief Investigator
Professor John Geddes
BFS
Bipolar Family Study
Chief Investigator
Professor Andrew McIntosh
Molecular Study
Molecular Genetic Investigation of Bipolar Disorder and Related Mood Disorder
Chief Investigator
Professor Nick Craddock
Emotional processing in Bipolar Disorder
Emotional processing in Bipolar Disorder
Chief Investigator
Dr Jess Sussmann
BISCIT
A pilot randomised controlled trial of Cognitive Behaviour Therapy for early bipolar disorder.
Chief Investigator
Dr Jamie Kirk



ProCEED
Evaluation of a system of structured, pro-active care for chronic depression in primary care
Chief Investigator
Dr Marta Buszewicz
SMaRT Oncology-2 Trial
Symptom Management Research Trials - SMaRT Oncology-2 Trial
Chief Investigator
Professor Michael Sharpe
SMaRT Oncology-3 Pilot
Symptom Management Research Trials - SMaRT Oncology-3 Pilot
Chief Investigator
Professor Michael Sharpe
SMaRT Oncology-3 Trial
Symptom Management Research Trials - SMaRT Oncology-3 Trial
Chief Investigator
Professor Michael Sharpe
GCIT
Evaluation of cognitive interpersonal group Evaluation of cognitive interpersonal group therapy for psychosis
Chief Investigator
Dr Christine Braehler
DTFI
Diffusion Tensor and Functional Imaging of Chronic Treatment Refractory Depression and Neurosurgical Treatments
Chief Investigator
Professor Douglas Steele
COBALT
Cognitive behavioural therapy as an adjunct to pharmacotherapy for treatment resistant depression in primary care: a randomised controlled trial
Chief Investigator
Dr Nicola Wiles
DBS
A clinical evaluation for the management of patients with Major Depressive Disorder, single or recurrent episode, with deep brain stimulation.
Chief Investigator
Professor Keith Matthews
SPECT
The effects of TNF blockade (using etanercept) on substrates of mood and cognition in patients with inflammatory arthritis.
Chief Investigator
Dr Jonathan Cavanagh
ISA
Inflammatory Bowel Disease, Steroids and Affective Disorder
Chief Investigator
Dr Benjamin Baig
CBASP
Intensive psychotherapy for chronic, treatment-resistant depression: a pilot investigation of clinical effectiveness and mediators of learning in the Cognitive Behavioural Analysis System of Psychotherapy (CBASP)
Chief Investigator
Mr John Swan
KANECT
The use of Ketamine as an anaesthetic during electroconvulsive therapy (ECT) for depression: does it improve treatment outcome?
Chief Investigator
Professor Ian Reid
ASPEN
Anti-Stigma Partnership European Network
Chief Investigator
Professor Graham Thornicroft
Identifying older heart failure patients with depression in primary care: a pilot study
Chief Investigator
Professor Marion McMurdo
AoDUS
Usability study of mental health information and support website
Chief Investigator
Dr Stephen Butler
Cognition and mood factors in the etiology of primary and secondary insomnia
Chief Investigator
Professor Colin Espie
ReMoDe
A feasibility study for a trial of Recovery versus Mindfulness models for Depression
Chief Investigator
Professor Margaret Maxwell
IPT-WCJS
Interpersonal Psychotherapy for Depression with Women Involved in the Criminal Justice System
Chief Investigator
Dr Suzie Black
CLICD
Counselling versus Low-Intensity Cognitive Behavioural Therapy for persistent subthreshold and mild Depression: A pilot/feasibility randomised controlled trial
Chief Investigator
Dr Elizabeth Friere
RePBAD
Reward Processing Brain Activity in Depression
Chief Investigator
Professor Douglas Steele
ASPIRE
Accessibility and implementation in UK services of an effective depression relapse prevention programme: Mindfulness-based cognitive therapy
Chief Investigator
Professor Jo Rycroft-Malone



iMANTRA-R
Internet-based relapse prevention for in-patients with Anorexia Nervosa
Chief Investigator
Professor Ulrike Schmidt



Scottish Family Genetic Colloboration
Scottish Family Genetic Collaboration
Chief Investigator
Professor Andrew McIntosh
GS SFHS
Generation Scotland: Scottish Family Health Study
Chief Investigator
Professor Andrew Morris
From genotype to psychiatric phenotype: serotonergic function in adults with Prader-Willi syndrome
Chief Investigator
Professor Sally-Ann Cooper
BDNF
Are differences in cognitive outcomes following Electro-convulsive Therapy (ECT) dependant on BDNF polymorphism status?
Chief Investigator
Professor Ian Reid



DownsLit
Genetically determined brain abnormalities in Down’s syndrome – towards a treatment
Chief Investigator
Professor Declan Murphy
A multi-centre phase 3 Cluster randomized controlled trial of a manualized anger management intervention for people with mild to moderate learning disabilities
Chief Investigator
Professor Paul Willner
NOVARTIS
A randomised, double blind, placebo-controlled, parallel group study to evaluate AFQ056 in adult patients with Fragile X Syndrome
Chief Investigator
Dr Andrew Stanfield
Impact of ADHD on the health and well-being of families.
Assessing the impact of children with ADHD on the health and well-being of their families.
Chief Investigator
Professor John Brazier
NOVARTIS
A randomised, double blind, placebo-controlled, parallel group study to evaluate AFQ056 in adolescent patients with Fragile X Syndrome
Chief Investigator
Dr Andrew Stanfield
ADDUCE
Attention Deficit Hyperactivity disorder Drugs Use Chronic Effects
Chief Investigator
Dr David Coghill
Fragxis
A randomised, double blind, 12 week, parallel group, placebo-controlled study of the efficacy and safety of RO4917523 in patients with fragile x syndrome
Chief Investigator
Dr Andrew Stanfield
The TOP-COG Study
Towards onset prevention of cognition decline in adults with Down syndrome
Chief Investigator
Professor Sally-Ann Cooper
BEAT IT
A randomised controlled trial comparing a behavioural activation treatment for depression in adults with learning disabilities with an attention control
Chief Investigator
Professor Andrew Jahoda
Domestic Violence and Women with Learning Disabilities
Chief Investigator
Dr Michelle McCarthy



A Neuropsychological Study of Emotion Regulation and Impulsivity
Chief Investigator
Professor Jeremy Hall
ENGAGE
Meeting mental health needs of complex co-morbid patients following a suicide attempt. A pilot study.
Chief Investigator
Professor Kate Davidson
The Edinburgh Emotional Symptoms Study
Chief Investigator
Professor Jeremy Hall



PODS
Persistence of distress in cancer outpatients: a symptom follow-up study
Chief Investigator
Professor Michael Sharpe



EDIE 2
Early Detection and Intervention Evaluation for individuals at high risk of psychosis (2)
Chief Investigator
Dr Anthony Morrison
PACT
Acceptance and Commitment Therapy for Psychosis
Chief Investigator
Dr Ross White
CR:ISP
Compassionate Recovery: Individualised Support in early Psychosis (CR:ISP). Implementing improvement strategies based on an Integrated Care Pathway for Early Psychosis
Chief Investigator
Professor Andrew Gumley
ADAPT
A Parallel group Randomised Open Blinded Evaluation of Acceptance and Commitment Therapy for Depression After Psychosis: A Pilot Trial (ADAPT)
Chief Investigator
Professor Andrew Gumley



Scottish Family Mental Health Study
Brain imaging studies of pre-frontal glutamate concentration, perfusion and activity.
Chief Investigator
Professor Stephen Lawrie
LD Rescan
Further studies of mental health in young people with additional learning needs.
Chief Investigator
Professor David Owens
Trust in Schizophrenia investigated with an Economics Game Paradigm
Chief Investigator
Dr James Currie
A single sequence, open-label, methodology study to assess cognitive change in patients with schizophrenia after supervised training with the Brain Fitness Program
Chief Investigator
The Benefit of Minocycline on Negative Symptoms in Schizophrenia: Extent and Mechanisms
Chief Investigator
Professor Bill Deakin
Roche negative
Study to evaluate efficacy and safety of RO4917838 in stable patients with persistent, predominant negative symptoms of schizophrenia treated with antipsychotics followed by a 28 week, doubleblind treatment period
Chief Investigator
Professor John Geddes
Roche sub-optimal
Study to evaluate the efficacy and safety of RO4917838 in patients with sub-optimally controlled symptoms of schizophrenia treated with antipsychotics followed by a 40-week double-blind, parallel group, placebo-controlled treatment period.
Chief Investigator
Professor John Geddes
Trust in Schizophrenia investigated with an Economics Game Paradigm (fMRI neuro-imaging Study)
Chief Investigator
Dr James Currie
FOCUS (Focus On Clozapine Unresponsive Symptoms)
Cognitive Behaviour therapy in treatment resistant schizophrenia
Chief Investigator
Professor Anthony Morrison
M10-855
A Randomized, Double-Blind, Placebo-Controlled, Dose-Ranging, Parallel-Group, Phase 2 Study of the Safety and efficacy of ABT-126 in the Treatment of Cognitive Deficits in Schizophrenia (CDS) in Nonsmokers.
Chief Investigator
Dr Sukhwinder Shergill
Impact of Illness
A cross-sectional survey and retrospective review of patients with persistent symptoms of schizophrenia to estimate their medical resource utilisation and burden of illness
Chief Investigator
Professor Stephen Lawrie
STEPWISE
Structured lifestyle Education for People with Schizophrenia
Chief Investigator
Professor Richard Holt



MSS
Multiple Symptom Study
Chief Investigator
Dr Chris Burton



BEST
Best Services Trial/Evaluation of the New Orleans Intervention for Infant Mental Health
Chief Investigator
Ms Helen Minnis
On Becoming a service user researcher: A national survey
Chief Investigator
Dr Tim Weaver
Investigating the neural basis for checking, selective attention and working memory in obsessive compulsive disorder, through MEG and TMS
Chief Investigator
Dr Klaus Kessler
Mellow Bumps
Antenatal parenting support for women vulnerable in pregnancy: an exploratory randomised controlled trial of Mellow Bumps
Chief Investigator
Professor Phil Wilson
Psychosexual support following prostate cancer surgery: Feasibility and outcomes of a couple-based intervention
Chief Investigator
Dr Liz Forbat
MCI
Memory and learning: cognitive processes underlying disorders of memory [Longitudinal Assessment of Short-term Memory Binding Functions in patients with Mild Cognitive Impairment]
Chief Investigator
Dr Mario Parra
A feasibility study of early identification, assessment and support for informal carers in primary care
Chief Investigator
Professor Scott Murray
TREM
Effectiveness and Acceptability of a Group Psychotherapy Intervention based on the Trauma, Recovery & Empowerment Model (TREM) for the Management of Mental Health Problems in Survivors of Complex Trauma
Chief Investigator
Professor Thanos Karatzias
E COG-DART
Edinburgh Cognitive Disorders Clinic, Diagnosis, Audit, Research and Treatment
Chief Investigator
Dr Suvankar Pal