Name:	Molecular Study
Title:	Molecular Genetic Investigation of Bipolar Disorder and Related Mood Disorder
Researchers:	Dr Ian Jones, Dr Lisa Jones, Bethan Flynn (Research Coordinator)
Funding Body:	The Wellcome Trust
Funding Awarded:	£1,207,579
Start Date:	01/04/2006
End Date:	31/03/2011

 

Summary

The aim is to identify and characterise genetic and environmental factors contributing to susceptibility to bipolar and psychotic illness.

Peer review publications arising from the poject

Publications specifically relating to the early data from this project include:
Hamshere ML, Green EK, Jones IR, Jones L, Moskvina V, Kirov G, Grozeva D, Nikolov I, Vukcevic D, Caesar S, Gordon-Smith K, Fraser C, Russell E, Breen G, St Clair D, Collier DA, Young AH, Ferrier IN, Farmer A, McGuffin P; Wellcome Trust Case Control Consortium, Holmans PA, Owen MJ, O'Donovan MC, Craddock N. Genetic utility of broadly defined bipolar schizoaffective disorder as a diagnostic concept. Br J Psychiatry. 2009 Jul;195(1):23-9. PubMed PMID: 19567891.

Project Results

Initial analysis (one small subset of target data) have demonstrated that variation at specific common gene variants is associated with susceptibility to mixed forms of bipolar mood and psychotic illness. Craddock N, Jones L, Jones IR, Kirov G, Green EK, Grozeva D, Moskvina V, Nikolov I, Hamshere ML, Vukcevic D, Caesar S, Gordon-Smith K, Fraser C, Russell E, Norton N, Breen G, St Clair D, Collier DA, Young AH, Ferrier IN, Farmer A, McGuffin P, Holmans PA; Wellcome Trust Case Control Consortium (WTCCC), Donnelly P, Owen MJ, O'Donovan MC. Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotype. Mol Psychiatry. 2010 Feb;15(2):146-53. Epub 2008 Jul 1. PubMed PMID: 19078961.